New drug protects monkeys from fentanyl overdose for a month

  • 2 Min To Read
  • 7 months ago

A new antibody medication shows promise in preventing the potentially life-threatening symptoms of a fentanyl overdose, according to a study conducted on monkeys. Fentanyl, a powerful opioid, has been a major contributor to the opioid crisis in North America, with millions of deaths attributed to its misuse. The medication, called CSX-1004, works by binding to the fentanyl molecule, preventing it from triggering harmful effects in the body.

In the study, monkeys were administered a high dose of fentanyl and then treated with a single infusion of CSX-1004. The results showed that the antibody treatment protected the monkeys from experiencing low respiratory rates, a common symptom of a fentanyl overdose, for almost a month. The monkeys also required significantly higher doses of fentanyl to experience the same decrease in respiration after treatment.

Additionally, CSX-1004 was found to blunt the pain-relieving effects of fentanyl, suggesting it could be used to treat addiction to the drug. The researchers did not observe any side effects of the treatment and found it to be effective against various fentanyl-like compounds. However, it does not work against other opioids, such as heroin or oxycodone.

The researchers are currently testing an injectable form of the antibody in humans, and a similar treatment targeting methamphetamine is also in clinical trials. While the results are promising, further research is needed, and the process of approving the drug for human use may take time. If successful, this medication could be a valuable tool in combating the opioid epidemic and reducing the risk of fentanyl-related deaths.


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