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What is known about the rare side effect 'Long Vax Syndrome'?

The phenomenon known as "Long Vax Syndrome" is gaining attention among researchers as they seek to better understand the potential side effects of the Covid-19 vaccine. Similar to the long-lasting symptoms experienced by some individuals with "Long Covid," Long Vax Syndrome is characterized by headaches, extreme fatigue, blood pressure issues, and abnormal heart rates that can persist for weeks or even longer. However, it is important to note that the number of reported cases of Long Vax Syndrome is significantly lower than the number of reported cases of Long Covid.

Studying this syndrome has been challenging due to the low number of reported cases and limited funding and support for research. A recent pre-print study described the experiences of 23 patients who reported nerve-related symptoms within a month of receiving the Covid-19 vaccine. These symptoms included severe sensations such as pins and needles in the face or limbs, as well as postural orthostatic tachycardia syndrome (POTS), heat intolerance, and irregular heartbeats.

Further testing confirmed the presence of POTS in some patients and revealed changes in the nerves, including abnormal swelling and reduced sweat production. These findings suggest a possible immune system reaction against nerve cells, leading to inflammation. Treatment with corticosteroids resulted in improvements for many patients.

It is important to note that this pre-print study has not yet been published in a peer-reviewed scientific journal. Other reports of POTS and related symptoms after Covid-19 vaccination have also been documented, but the incidence appears to be significantly lower than after SARS-CoV-2 infection.

Recognizing the potential significance of these findings, researchers at Yale University have launched the LISTEN Study to investigate Long Covid, post-vaccine adverse events, and immune responses. The study aims to collect information and samples from individuals experiencing unusual symptoms after Covid-19 vaccination.

While the potential benefits of the Covid-19 vaccine outweigh the risks of Long Vax Syndrome and other possible side effects, it is crucial to investigate and address any legitimate concerns. It is important to differentiate between unfounded claims and genuine problems experienced by individuals. Further research is needed to fully understand the incidence and mechanisms of Long Vax Syndrome.

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